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GeneMate® Breast & Ovarian

Test your hereditary risk of breast and ovarian cancers. GeneMate® Breast & Ovarian includes all genes associated with hereditary breast and/or ovarian cancers for which there are medical management recommendations. While GeneMate® BRCA+ only analyses genes associated with a highly increased risk, GeneMate® Breast & Ovarian analyzes several additional genes associated with a moderately increased risk. Some analyzed genes are associated with rare hereditary cancer syndromes, for which breast cancer may be a symptom

Genes: ATM, CHEK, TP53, PALB2, BRCA1, BRCA2, PTEN, NF1, STK11, CDH1, RAD51C, RAD51D, BARD1, BRIP1

What's included

Saliva collection kit + shipping

State-of-the-art DNA analysis

Clinical interpretation

Connection to continued care (when needed)

3 595SEK

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Breast

Ovaries

Genes and cancer types
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Who is GeneMate® Breast & Ovarian best suited for?

Women with a family history of breast, ovarian, prostate, and/or pancreatic cancer.

Women who been diagnosed with ovarian cancer or triple negative breast cancer.

Women who have been diagnosed with breast cancer with a family history of breast, ovarian, prostate, and/or pancreatic cancer.

Women with a family history of breast cancer and one of the below, or women who have been diagnosed with breast cancer and have a family history of one of the below

  • Diffuse stomach cancer
  • Thyroid, colorectal, or uterine (endometrial) cancer
  • Retinoblastoma or any other symptom related to Neurofibromatosis 1
  • Sarcoma, brain tumors, and/or adrenal cortex cancer
  • Colorectal, stomach, pancreatic, and gynecological cancer

Not all cancers need to present in the family in order to suspect hereditary cancer. Early onset of cancer or several instances of the same or genetically related cancer types in a family increase the likelihood that it is hereditary. Women with ovarian cancer or triple negative breast cancer are recommended genetic testing despite a lack of family history.

Recommendations for who should undergo evaluation and genetic testing for hereditary breast cancer can be found here

What does a positive GeneMate® Breast & Ovarian test mean for my risk?

How much your risk is increased and for which cancer(s) depends on which gene is varied, as well as your family history including age at diagnosis.

Women who’s GeneMate® Breast & Ovarian test is positive could have an moderately to highly increased lifetime risk of breast and ovarian cancer.

In some cases, risk may also be increased of other cancers including stomach, thyroid, uterine (endometrial), colorectal, or adrenal cortex cancer, as well as sarcoma and brain tumors.

How can I manage my risk if my test is positive?

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Healthy carriers can take action to reduce their risk of developing cancer or to detect cancer early for a better prognosis. Which actions to take, at what age, and with which frequency varies depending on family history and which gene is varied

Healthy women with an increased risk of breast cancer may be offered mammography screening and/or MRI of the breasts or surgical removal of the breasts with the intent of preventing breast cancer.

Healthy women with an increased risk of gynecological cancers may be offered surgical removal of ovaries and fallopian tubes and/or uterus with the intent of preventing cancer in these organs.

Healthy women may also be offered additional screening for thyroid, colorectal, kidney, stomach, small bowel, pancreatic, and, uterine (endometrial) cancer.

3 595SEK

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