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GeneMate® Colon

Test your hereditary risk for colorectal cancer. GeneMate® Colon includes all genes associated with hereditary colorectal cancer for which there are medical management recommendations. While certain genes are also associated with hereditary gynecological cancers, GeneMate® Colon does not provide a comprehensive assessment of these cancers. For a comprehensive assessment of your hereditary uterine (endometrial) and ovarian cancer risk, please refer to GeneMate® Breast, Gyn, & Colon or GeneMate® PREMIUM.

Genes: APC, EPCAM, MLH1, MSH2, MSH6, PMS2, MUTYH

What's included

Saliva collection kit + shipping

State-of-the-art DNA analysis

Clinical interpretation

Connection to continued care (when needed)

2 995SEK

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Colorectal

Uterus

Bladder

Genes and cancer types
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Who is GeneMate® Colon best suited for?

Women

Men

Women with a family history of:

  • Colorectal, uterine (endometrial), ovarian, urinary tract, stomach, and/or small bowel cancer

Women who have been diagnosed with one or several of the following cancers:

  • Uterine (endometrial) cancer
  • Ovarian cancer
  • Colorectal cancer
  • Urinary tract cancer
  • Stomach cancer
  • Small bowel cancer

Not all cancers need to present in the family in order to suspect hereditary cancer. Early onset of cancer or several instances of the same or genetically related cancer types in a family increase the likelihood that it is hereditary. Women with ovarian cancer or triple negative breast cancer are recommended genetic testing despite a lack of family history.

Men with a family history of:

  • Colorectal, uterine (endometrial), ovarian, urinary tract, stomach, and/or small bowel cancer

Men who have been diagnosed with one or several of the following cancers:

  • Colorectal cancer
  • Urinary tract cancer
  • Stomach cancer
  • Small bowel cancer

Not all cancers need to present in the family in order to suspect hereditary cancer. Early onset of cancer or several instances of the same or genetically related cancer types in a family increase the likelihood that it is hereditary. Women with ovarian cancer or triple negative breast cancer are recommended genetic testing despite a lack of family history.

What does a positive GeneMate® Colon test mean for my risk?

How much your risk is increased and for which cancer(s) depends on which gene is varied, as well as your family history including age at diagnosis.

Women

Men

Women who’s GeneMate® Colon test is positive could have an increased lifetime risk of one or more of the following cancers:

Moderately to highly increased risk for colorectal cancer

Moderately to highly increased risk for uterine (endometrial) cancer

Moderately increased risk for ovarian cancer

In some cases, risk may also be increased of other cancers including bladder, stomach, and small bowel cancer.

Men who’s GeneMate® Colon test is positive have an increased lifetime risk of colorectal cancer.

In some cases, risk may also be increased of other cancers including bladder, stomach, and small bowel cancer.

How can I manage my risk if my test is positive?

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Healthy carriers can take action to reduce their risk of developing cancer or to detect cancer early for a better prognosis. Which actions to take, at what age, and with which frequency varies depending on family history and which gene is varied

Women

Men

Healthy women with an increased risk of colorectal cancer may be offered colonoscopy and/or endoscopy screening or surgical removal of the colon with the intent of preventing colon cancer.

Healthy women with an increased risk of gynecological cancers may be offered surgical removal of ovaries and fallopian tubes and/or uterus with the intent of preventing cancer in these organs.

Healthy women may also be offered additional screening for bladder cancer.

Healthy men with an increased risk of colorectal cancer may be offered colonoscopy and/or endoscopy screening or surgical removal of the colon with the intent of preventing colon cancer.

Healthy men may also be offered additional screening for bladder cancer.

2 995SEK

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