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GeneMate® Breast, Gyn, & Colon

Test your hereditary risk of Breast, Gynecological, and colorectal cancers. GeneMate® Breast, Gyn, & Colon includes all genes associated with hereditary breast, ovarian, uterine, and colorectal cancers for which there are medical management recommendations. In addition to analyzing genes associated with a highly and moderately increased risk of breast and ovarian cancer (including rare and hereditary cancer syndromes where breast cancer may be a symptom), this test includes genes primarily associated with uterine (endometrial) cancer and colorectal cancer (Lynch syndrome).

Genes: ATM, CHEK, TP53, PALB2, BRCA1, BRCA2, BRIP1, RAD51C, RAD51D, BARD1, PTEN, NF1, STK11, CDH1, APC, MUTYH, EPCAM, MLH1, MSH2, MSH6, PMS2

What's included

Saliva collection kit + shipping

State-of-the-art DNA analysis

Clinical interpretation

Connection to continued care (when needed)

4 295SEK

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Breast

Colorectal

Ovaries

Uterus

Bladder

Genes and cancer types
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Who is GeneMate® Breast, Gyn, & Colon best suited for?

Women

Men

Women with a family history of either:

  • Breast, ovarian, prostate, and/or pancreatic cancer
  • Colorectal, uterine (endometrial), ovarian, urinary tract, stomach, and/or small bowel cancer

Women who have been diagnosed with one or several of the following cancers:

  • Breast cancer
  • Ovarian cancer
  • Breast cancer
  • Uterine (endometrial) cancer
  • Colorectal cancer
  • Urinary tract cancer
  • Stomach cancer
  • Small bowel cancer

Not all cancers need to present in the family in order to suspect hereditary cancer. Early onset of cancer or several instances of the same or genetically related cancer types in a family increase the likelihood that it is hereditary. Women with ovarian cancer or triple negative breast cancer are recommended genetic testing despite a lack of family history.

Men with a family history of either:

  • Breast, ovarian, prostate, and/or pancreatic cancer
  • Colorectal, uterine (endometrial), ovarian, urinary tract, stomach, and/or small bowel cancer

Men who have been diagnosed with one or several of the following cancers:

  • Colorectal cancer
  • Urinary tract cancer
  • Stomach cancer
  • Small bowel cancer

Not all cancers need to present in the family in order to suspect hereditary cancer. Early onset of cancer or several instances of the same or genetically related cancer types in a family increase the likelihood that it is hereditary. Women with ovarian cancer or triple negative breast cancer are recommended genetic testing despite a lack of family history.

What does a positive GeneMate® Breast, Gyn, & Colon test mean for my risk?

How much your risk is increased and for which cancer(s) depends on which gene is varied, as well as your family history including age at diagnosis.

Women

Men

Women with a family history of either who’s GeneMate® Breast, Gyn,, & Colon test is positive could have an increased lifetime risk for one or more of the following cancers:

Moderately to highly increased risk for colorectal cancer (Lynch genes)

Moderately to highly increased risk for breast cancer (most genes)

Moderately to highly increased risk for ovarian cancer (some genes)

Moderately to highly increased risk for uterine (endometrial) cancer (Lynch genes)

In some cases, risk may also be increased of other cancers including bladder, stomach, small bowel, thyroid, bile duct, or adrenal cortex cancer, as well as sarcoma and brain tumors.

Men who’s GeneMate® Breast, Gyn,, & Colon test is positive could have an increased lifetime risk for one or more of the following cancers:

Moderately to highly increased risk for prostate cancer (BRCA2 or MSH2)

Moderately to highly increased risk for colorectal cancer (Lynch genes)

In some cases, risk may also be increased of other cancers including bladder, stomach, small bowel, thyroid, bile duct, or adrenal cortex cancer, as well as sarcoma and brain tumors.

How can I manage my risk if my test is positive?

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Healthy carriers can take action to reduce their risk of developing cancer or to detect cancer early for a better prognosis. Which actions to take, at what age, and with which frequency varies depending on family history and which gene is varied.

Women

Men

Healthy women with an increased risk of breast cancer may be offered mammography screening and/or MRI of the breasts or surgical removal of the breasts with the intent of preventing breast cancer.

Healthy women with an increased risk of gynecological cancers may be offered surgical removal of ovaries and fallopian tubes and/or uterus with the intent of preventing cancer in these organs.

Healthy women with an increased risk of colorectal cancer may be offered colonoscopy and/or endoscopy screening or surgical removal of the colon with the intent of preventing colon cancer.

Healthy women may also be offered additional screening for bladder, thyroid, kidney, and pancreatic cancer.

Healthy men with an increased risk of prostate cancer (if variant in BRCA2) may be offered additional prostate screening in the form of PSA testing and palpation.

Healthy men with an increased risk of colorectal cancer may be offered colonoscopy and/or endoscopy screening or surgical removal of the colon with the intent of preventing colon cancer.

Healthy men may also be offered additional screening for bladder, thyroid, kidney, stomach, and pancreatic cancer.

4 295SEK

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