GeneMate® Breast, Gyn & Colon
| Gene | Cancer syndrome | Most common cancers associated with a risk variant in each gene |
|---|---|---|
| ATM CHEK2 BARD1 |
Hereditary breast amd ovarian cancer (HBOC) Hereditary prostate cancer (BRCA2) |
Breast cancer |
| BRCA1 BRCA2 PALB2 RAD51C RAD51D |
Breast cancer and ovarian cancer. Hereditary prostate cancer (BRCA2) |
|
| BRIP1 | Ovarian cancer | |
| PTEN | PTEN hamartoma tumor syndrome (PHTS) | Breast cancer, thyroid cancer, uterine (endometrial) cancer, and colorectal cancer. |
| CDH1 | Hereditary diffuse gastric cancer | Diffuse stomach cancer and lobular breast cancer |
| NF1 | Neurofibromatosis 1 | Several cancers, including breast cancer |
| TP53 | Li-Fraumeni | Several cancers, including breast cancer, sarcoma, brain tumors, and adrenal cortex cancer |
| STK11 | Peutz-Jeghers syndrome (PJS) | Several cancers, including breast cancer, colorectal cancer, and gynecological cancer |
| EPCAM MLH1 MSH2 MSH6 PMS2 |
Lynch syndrome | Colorectal cancer, uterine (endometrial) cancer, ovarian cancer, urinary tract cancer, stomach cancer, and small bowel cancer. |
| MUTYH | MUTYH-associated polyposis (MAP) | Colorectal cancer |
| APC | Familial adenomatous polyposis (FAP) | Colorectal cancer |